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爪蟾蝌蚪胚胎发育毒性实验Tadpole embryonic developmental toxicity testing

以非洲爪蟾胚胎 / 蝌蚪为模型，评价环境因子与化合物对早期发育的影响，开展致畸、致死与发育异常的系统观察（FETAX 思路），适用于环境毒理与药物安全评价。Using Xenopus embryos/tadpoles to assess effects of environmental factors and compounds on early development — teratogenicity, lethality and abnormalities (FETAX-style).

检测能力Capabilities

  • FETAX：爪蟾胚胎致畸与致死测试FETAX: frog embryo teratogenesis assay
  • 发育终点：存活率、畸形率、体长、心率、行为Endpoints: survival, malformation, length, heart rate, behavior
  • 神经 / 心脏毒性：神经发育与心脏功能评价Neuro/cardiotoxicity: neural & cardiac assessment
  • 分子毒理：转录组、信号通路（如 Notch）分析Molecular: transcriptomics & pathway (e.g. Notch) analysis
  • 受试物：农药、双酚类、内分泌干扰物、纳米材料、电离辐射等Test items: pesticides, bisphenols, EDCs, nanomaterials, ionizing radiation
环境因子与胚胎发育
代表性成果Selected publications

客户使用本服务发表的论文（节选）Client papers using this service

完整名单见 客户 SCI 论文精选。Full list: client SCI papers.

Environmental Research2024
Ionizing radiation induces neurotoxicity in Xenopus laevis embryos
Hou et al. · Environ Res 256:119237 · 电离辐射神经毒性Radiation neurotoxicity
DOI
Environmental Pollution2024
Mitochondrial dynamics disruption: unraveling dinotefuran's impact on cardiotoxicity
Zhu et al. · Environ Pollut 343:123238 · 呋虫胺心脏毒性Dinotefuran cardiotoxicity
DOI
J Hazardous Materials2021
The combined adverse effects of cis-bifenthrin and graphene oxide
Li et al. · J Hazard Mater 407:124876 · 联苯菊酯 + 氧化石墨烯cis-Bifenthrin + graphene oxide
DOI
Environmental Pollution2020
Effects of bisphenol A and its alternative bisphenol F on Notch signaling
Zhu et al. · Environ Pollut 263(Pt B):114443 · 双酚 A/F 与 NotchBisphenol A/F & Notch
DOI
Science Total Environ2020
Transcriptional changes caused by estrogenic endocrine disrupting chemicals
Shen et al. · Sci Total Environ 726:138522 · 雌激素内分泌干扰物Estrogenic EDCs
DOI
Aquatic Toxicology2020
Transcriptomic analysis identifies early cellular and molecular toxic events
Li et al. · Aquat Toxicol 226:105557 · 发育毒性转录组Developmental toxicogenomics
DOI
Toxicology2020
d-Glucuronolactone attenuates para-xylene-induced developmental defects
Liao et al. · Toxicology 430:152341 · 对二甲苯发育缺陷para-Xylene defects
DOI

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